I have peripheral neuropathy, both legs, worse in the left in terms of discomfort but my left leg is stronger than my right. I started about 2-3 weeks ago taking 1,000 mcg sublingual methyl cobalamin but, for me, I can’t tell that it’s made any difference, yet. I still have trouble getting to sleep at nights because of the discomfort. Oddly enough, the thing that has helped, is I started taking a Benadryl before bedtime because I had been a bit congested. I found out it apparently makes me a bit more drowsy and I’ve been falling asleep faster. Here’s the B12 I mentioned if you want to try it. You want sublingual because B12 can be degraded pretty quickly by stomach fluids unless it is first bound to a compound in your saliva. https://horbaach.com/products/b12-methylcobalamin-1000mcg-400-sublingual-tablets
Thanks .... I just started on the same thing [different brand]. As you said no real relief yet . I was just wondering [and hoping] if perhaps someone else has experienced actual relief. Everything I read about it is positive so we'll see.
Sounds like you are expecting a miracle from the B12, Do you know what your labs were before you started. I never heard of B12 for PN and I've dealt with PN and been around many who have and never talk about B12. I've read for years many are generally deficient and best to get lab test on this one.
Not looking for any miracles ..... Although I'll gladly take one. And , as i said .. I have read allot of sites with positive ermarks about B12 for neuropathy , otherwise I wouldn't have tried it.
Well again, you need to know if you are deficient, lab tests....and as I said I've been dealing with neuropathy people for many yrs and never heard that B12 for nerve damage.....Energy Yes.....
Don't know what to tell you ... Here are three. Just because you might not agree , doesn't mean it is not worth trying. https://foxintegratedhealthcare.com...s, supplementing with,can be helpful for some. https://pubmed.ncbi.nlm.nih.gov/32722436/ https://goldcoastchiropractic.com/how-much-b12-is-needed-for-neuropathy/
This raises a couple of questions: 1-How does one define "deficient"? By whose standard? Whenever the US RDA is mentioned, most of us [metaphorically] spit on the ground. So even if one gets tests (I'm waiting for the results of mine as we speak), what reference does one use as the standard to evaluate the results? And some tests are not cheap. Plus there's the blood draw fees. 2-Even if one is not "deficient," aren't there many instances with many vitamins/minerals where higher doses are beneficial? I know there are lots of COVID protocols out there that recommend very high levels of zinc, vitamin C, vitamin D, and others both as a prophylactic and as a treatment. The main things I would (and do) investigate are the direct risks of over-supplementing, and the subordinate risks of causing deficiencies of other vitamins/minerals.
I have brought up the Swiss study of many years ago before. That involved thyroid values but the principles apply to almost everything. The RDAs published by the government generally state the amount that is required to avoid vitamin or mineral deficiency disease/syndrome, but they are NOT necessarily the OPTIMUM amounts of that nutrient, whatever it is. Optimum amounts are generally many times the RDA that simply prevents disease. Vitamin D is a prime example. I remember when medicine claimed that 10,000 IU would be a fatal dose. It was claimed without ever being tested.
I finally got the results of that micronutrient lab test I had done almost 60 days ago. The report says it was completed the middle of last month, and it took a while for me to shake it loos from the pharmacy I bought it through. For the curious, I've attached a copy of the report with my personal stuff redacted. Here are highlights of the issues this found. Keep in mind that this is my non-supplementing state (I dried out for surgery and for this test), with the exception of the 200mg/day CoQ10 I continued to take with my statin. ******************************************* Coenzyme Q10 DEFICIENT (Pg 3) Me 86%. Should be > 86% Vitamin B2 DEFICIENT (Pg 3) Me 52%. Should be >53% Vitamin C DEFICIENT (Pg 3) Me 38%. Should be >40% Chromium (Pg 3) BORDERLINE DEFICIENT Oleic Acid (Pg 3) BORDERLINE DEFICIENT B5 Pantothenate (Pg 3) BORDERLINE DEFICIENT Zinc (Pg 3) BORDERLINE DEFICIENT Total Antioxidant Function AVERAGE (Pg 3) Total Immune Function AVERAGE (Pg 3) ******************************************* All of these will be remediated once I start supplementing again, assuming I don't have an issue metabolizing any of them (and the slight deficiencies don't indicate that.) I'm a little disappointed that I've let my dietary habits slide, substituting some amount of eating out (and the attendant fried foods) for my homemade meals. A better diet might give me higher Antioxidant Function and Immune Function numbers (they are just Average.) That being said, the only things barely crossing the deficiency threshold are B2 and Vit C. The CoQ10 is likely statin-caused, and I had been taking twice as much before I dried out for the test. Anyway, it's an interesting report.
John, I never did the type test you have done, I just started supplementing at mid 50's as I knew body needed some repair work and it just made sense. As everything gets old, it needs help. Just hope that the statin does not do a trip on your memory...j Oh and I'm hearing more and more that "they" are injecting the MRNA bulleheet in animals and now being told to avoid a lot of meats...or buy from reputable suppliers....ggrrrrrr Working toward that Depopulation goal....
I've been supplementing heavily since 1990, and this is the first time I've had a test like this done. I might do it again next year WITH supplements to see how things are, but this round I needed a shot at my clean system. Regarding statins: I've been taking coconut oil most every evening to replenish the healthy fats. I continue to be on the fence regarding statins. I've read the same thing you have regarding MRNA in our food. "Reputable grocer" has no idea what's in his beef. Reputable rancher would, and reputable butcher might. The issue is gonna be if the USDA requires the MRNA shots. If it does, then no MRNA-free beef can get processed for sale to the public.
FWIW, the half life of synthetic mRNAs appears to be, from just a quick look at the literature, from anywhere between a few minutes to about 10 hours, depending on structure, host organism, etc.
I struggle to find consistent, reliable information on supplements, especially interactions among different supplements and between supplements and pharmaceuticals. The most recent example is taking Vitamin C and Zinc together. Many websites state that C represses absorbing zinc, while others say "No problem!" Of course, I take the most conservative position. This is a real issue when you have an extensive supplement program (meaning I take a variety of things in moderate doses.) I spread things out over the day, taking a morning group, an afternoon group and an evening group. It can also be an issue if for some reason I need to take an antibiotic (which presents the most common pharmaceutical/supplement interaction.) While I always read a variety of sites, I find that ConsumerLabs seems to have the most in-depth consistent write-ups, with a Reader Comments area on the articles. There is a free area, with full articles and all Reader Comments being accessible to Subscribers Only. It's not expensive, but it's more than a token amount, at $5/month. I know there are lots of free sites out there, but I want one I can rely on to give me in-depth information that's not a copy/paste of others. Has anyone here ever subscribed to this? What are your thoughts? I just signed up for their free 2x/week newsletter plus Sunday Summary to test the waters.
So I did a Deep Dive into the micro-nutrient test results that I got. I transcribed the data to a spreadsheet and took a look at the things I am either Deficient, Borderline, or Lower-End-Of-Good in. With one exception, I am already supplementing all of those items through individual supplements and/or as a component of my multi-vitamin. The one exception is the non-essential amino acid Asparagine. The results say I'm good...Target is >39% and I'm 45%, but I think my 45% is the low end (more on the scale's issues below.) When I do a little reading, I find that studies are in conflict as to whether Asparagine prevents or feeds cancer cells. So I'll leave it alone and not over-supplement it. Regarding trying to decipher this test's scale... I cannot figure out the threshold for Deficient/Borderline/Good. -Pantothenate target is >7%, I'm at 12%, which it evaluates as Borderline -Choline target is >20%, I'm at 25%, which it evaluates as Good. --Both of those are an absolute 5% off, but my Pantothenate is 71% above Target while Choline is only 25% above Target. So why would my Pantothenate be Borderline and my Choline be Good? Then there's the graph they use. This is for my B1 and B2: I drew that black line at the halfway (50%) mark. B1: The Reference Range is >78%. That's where the green (Good) should start. But the green starts well below the halfway mark. And Patient Results are 99%, where the white circle is in the green area. There's tons of room to the right of the supposed 99% circle. B2: The Reference Range is >53%, so the green starts at about the right spot. But my 52% red Deficient circle is way more than 1% under that. So I don't understand the scale. And what do the percentages really mean? Looking at the B1 data, exactly what am I 99% of, and what is the top end of that scale? Also, I'm assuming that Patient Results have an implied "%" after them. I sent the lab's Customer Support an email yesterday to ask for details (yeh, I'm a pain in the butt.) I've not heard back yet.