Interesting Science Stuff

Discussion in 'Science & Nature' started by Thomas Windom, Mar 6, 2023.

  1. Mary Stetler

    Mary Stetler Veteran Member
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    #61
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  2. Beth Gallagher

    Beth Gallagher Supreme Member
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  3. Thomas Windom

    Thomas Windom Very Well-Known Member
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    I just this A.M. saw this article and thought about the above post.

    https://phys.org/news/2023-04-arctic-ice-algae-heavily-contaminated.html
     
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  4. Thomas Windom

    Thomas Windom Very Well-Known Member
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  5. Thomas Windom

    Thomas Windom Very Well-Known Member
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    Colistin is a last line antibiotic used against infectious agents that have become resistant to everything else. Now, a bacteria that has become resistant to Colistin, may also be becoming resistant to humans’ innate immune system itself.

    “Colistin is an AMP derived from a bacillus bacteria once used widely in agriculture beginning in the 1980s. After a breakout of colistin-resistant E. coli in China, the practice was banned in 2016. Colistin is now primarily used for severe infections resistant to multiple other antibiotics. It is a last line of defense when other options have failed, so the pathogenic evolution of resistance to colistin would have terrible consequences. What the researchers found in their study hints at something far worse.”

    https://medicalxpress.com/news/2023-04-colistin-resistant-coli-gains-resistance-innate.html
     
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  6. Thomas Windom

    Thomas Windom Very Well-Known Member
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  7. Thomas Windom

    Thomas Windom Very Well-Known Member
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    A.I. to the rescue again. Researchers realized that natural language processing A.I.s looked like good candidates for figuring out molecular coding of mRNA since the sequences making up the molecular could be thought of as a type of language. How complex is this task?

    “For instance, there are approximately 10(exponent632) mRNAs that can be translated into the same SARS-CoV-2 Spike protein, presenting insurmountable challenges for prior methods.”

    “Though NLP and biology may at first glance appear unrelated, the two fields share strong mathematical connections. In human language, a sentence consists of a word sequence and an underlying syntactic tree with noun and verb phrases, which together convey meaning. Likewise, an RNA strand has a nucleotide sequence and an associated secondary structure based on its folding pattern.”

    “Using this approach, LinearDesign takes a mere 11 minutes to generate the most stable mRNA sequence that encodes Spike protein.”

    “In a head-to-head comparison, the sequences designed by LinearDesign exhibited significantly improved results compared to existing vaccine sequences. For COVID-19 mRNA vaccine sequences, the algorithm achieved up to a 5-fold increase in stability (mRNA half-life), a 3-fold increase in protein expression levels (within 48 hours), and an incredible 128-fold increase in antibody response. For VZV mRNA vaccine sequences, the study reported up to a 6-fold increase in stability (mRNA molecule half-life), a 5.3-fold increase in protein expression levels (48 hours), and an 8-fold increase in antibody response.”

    https://medicalxpress.com/news/2023-05-ai-algorithm-boost-covid-mrna.html
     
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  8. John Houlihan

    John Houlihan Very Well-Known Member
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    I watched a very enjoyable movie last night called "Interstellar". If you like science fiction, this is a good one!
     

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  9. Mary Stetler

    Mary Stetler Veteran Member
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    Still not doing it.
    But if a biological war breaks out, maybe it would be useful for some.
     
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  10. Thomas Windom

    Thomas Windom Very Well-Known Member
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    Sending women to space makes lots of sense (and $$$).

    ”According to NASA, the cost of getting payloads to the International Space Station (ISS) is $93,400 per kg. The study found that on a 1080-day mission, a four-member all-female crew would require 1695 kg less food weight. With some simple arithmetic, the mission could save over $158 million and free up 2.3 m3 of space (food packaging), the equivalent of approximately 4% of the habitable volume (60 m3) of a "Gateway" HALO module in NASA's proposed lunar orbit space station. Both factors would be highly significant operationally, but there is more.

    Compared to a previous study of theoretical male astronauts, the effect of body size on total energy expenditure was markedly less in females, with relative differences ranging from 5% to 29% lower. Compared at the 50th percentile stature for US females (1.6m), the reductions were even more significant at 11% to 41%. This translates into reduced use of oxygen, production of CO2, metabolic heat, and water use.”

    https://phys.org/news/2023-05-female-astronauts-efficient-future-space.html
     
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  11. Beth Gallagher

    Beth Gallagher Supreme Member
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    Gee, I hope they expanded that study to include tranny females. Wouldn't want them getting all butt-hurt.
     
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  12. Thomas Windom

    Thomas Windom Very Well-Known Member
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    I think they would be all outraged to find that they measure just like most males, albeit, maybe on the lower end of the spectrum because of injecting themselves with hormones and whatever else.
     
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  13. Thomas Windom

    Thomas Windom Very Well-Known Member
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    OK, this one is weird, very counterintuitive. We are going to give it a try (adjusting grind to coarser) since it’s easy to test. The claim is that extremely finely ground coffee used in making espresso, tends to pack too well, creating channels when the pressurized water is forced through, instead of evenly flowing through, thereby over-extracting some areas of the coffee puck and under-extracting others.

    https://phys.org/news/2020-01-brewing-espresso-shot-math.html

    It doesn’t make sense to me though because I could not tell the difference between an espresso and a cup of Turkish brew using the same coffee and grind. In Turkish coffee brewing, there is no possibility for non-uniform extraction because the coffee grains are free floating in the brew and most are even consumed with the coffee.
     
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  14. Thomas Windom

    Thomas Windom Very Well-Known Member
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    I really like these serendipitous discoveries in science. This one could have a huge benefit in imaging, especially medical.

    ”A team of researchers, jointly led by the Universities of Oxford and Cambridge, have discovered that a solar cell material—bismuth oxyiodide (BiOI)—is capable of detecting X-ray dose rates over 250 times lower than the current best performing detectors used commercially. This has the potential to make medical imaging safer, and open up new opportunities in non-invasive diagnostics, such as X-ray video techniques. Their results are reported in the journal Nature Communications.”

    https://phys.org/news/2023-05-sustainable-solar-cell-material-shown.html
     
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  15. Thomas Windom

    Thomas Windom Very Well-Known Member
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